Decoupling disease from wasting
Why does someone with cancer necessarily have to suffer from fatigue, weakness and loss of appetite? Why do we assume that one must follow the other? Daniel Marks, MD PhD, seeks to understand the causes of cachexia (wasting syndrome) as a condition separate from the underlying disease itself. The severity of cachexia in many illnesses is the primary determining factor in both quality of life, and in eventual mortality. Dr. Marks and his Daniel Marks Lab are working to identify the brain signals that chronic diseases send to trigger cachexia. If a patient’s cachexia can be effectively treated, she will have the nutrition and strength she needs to confront cancer or other chronic diseases. She will be more resilient.